Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction
نویسندگان
چکیده
An efficient, two-step construction of highly complex alkaloid-like compounds from the natural product fumagillol is described. This approach, which mimics a biosynthetic cyclase/oxidase sequence, allows for rapid and efficient structure elaboration of the basic fumagillol scaffold with a variety of readily available coupling partners. Mechanistic experiments leading to the discovery of an oxygen-directed oxidative Mannich reaction are also described.
منابع مشابه
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عنوان ژورنال:
دوره 16 شماره
صفحات -
تاریخ انتشار 2014